We written a broad model understand the relationship between gene phrase and transcription distance

We written a broad model understand the relationship between gene phrase and transcription distance

A detailed derivation of the model, that have associated cards with the presumptions and you will simplifications, is during Si Information and methods. About design, interpretation try separated into about three phases; “transcriptional interpretation” (translation while in the mRNA transcription), “in-transportation interpretation” (translation started during the transcription and done once mRNA discharge), and you may “posttranscriptional interpretation” (interpretation initiated and you can finished once mRNA release) (Fig. step threeA).

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Model of operon transcription and translation. (A) Translation during transcription (transcriptional translation) and following mRNA release (posttranscriptional translation). ?step one, ?2, and ?3 are the transcription distances for genes 1, 2, and 3, respectively. (B) The contributions of transcriptional, in-transit, and posttranscriptional translation to the total protein in the cell. The estimated in-transit translation assumes the translation and transcription rates in units of codons per second are approximately equal.

Transcriptional translation can commence once the start codon of a gene is transcribed and continues until the RNA polymerase encounters the terminator and releases the mRNA. The amount of time available for transcriptional translation is therefore determined by the transcription distance (?) divided by the transcription rate (?) minus the lag time to create the first protein. 1; units of codons per second). Multiplying this time period by the rate of protein production (?1; units are proteins per mRNA per second) gives the amount of transcriptional translation per mRNA, which is By definition L ? ? (more…)

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